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The computational server for this study was supported by the Medical Science Data Center at Shanghai Medical College of Fudan University and the High-performance Computing Platform of Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College
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4.5 Serine, glycine, and threonine Serine, glycine, and threonine are closely linked to one-carbon metabolism within the metabolic network and determine the metabolic module of “one-carbon metabolism-nucleotide synthesis-methyl donor generation-redox homeostasis.” Unlike arginine or tryptophan, which are more oriented toward regulation through the “effector molecule/receptor signaling axis,” these amino acids more commonly influence inflammation-related gene expression and epigenetic states by affecting processes such as nucleotide synthesis, NADPH supply, and methyl donor generation (39, 63)
